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My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.
Jack W. Szostak
A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
Frederick Sanger
As to Science, she has never sought to ally herself to civil power. She has never attempted to throw odium or inflict social ruin on any human being. She has never subjected anyone to mental torment, physical torture, least of all to death, for the purpose of upholding or promoting her ideas. She presents herself unstained by cruelties and crimes. But in the Vatican—we have only to recall the Inquisition—the hands that are now raised in appeals to the 'Most Merciful' are crimsoned. They have been steeped in blood!
John William Draper
The teacher manages to get along still with the cumbersome algebraic analysis, in spite of its difficulties and imperfections, and avoids the smooth infinitesimal calculus, although the eighteenth century shyness toward it had long lost all point.
Felix Klein
... the irregularities of the motion of Uranus...in order to find out whether they may be attributed to the action of an undiscovered planet beyond it.[John Couch Adams on how he began to discover Neptune.]
John Couch Adams
For [Wolfgang] Pauli the central problem of electrodynamics was the field concept and the existence of an elementary charge which is expressible by the fine-structure constant ... 1/137. This fundamental pure number had greatly fascinated Pauli, .... For Pauli the explanation of the number 137 was the test of a successful field theory, a test which no theory has passed up to now.
Charles P. Enz
Another very good test some readers may want to look up, which we do not have space to describe here, is the Casimir effect, where forces between metal plates in empty space are modified by the presence of virtual particles.Thus virtual particles are indeed real and have observable effects that physicists have devised ways of measuring. Their properties and consequences are well established and well understood consequences of quantum mechanics.
Gordon L. Kane
At his "World of Physics" Web site, Eric W. Weisstein notes that the fine structure constant continues to fascinate numerologists, who have claimed that connections exist between alpha, the Cheops pyramid, and Stonehenge!
Clifford A. Pickover
If the universe was scientific and just left to itself, then we’d have statistical probabilities to rely on. But once people are involved it sometimes becomes much more problematic because they’re erratic. People do crazy things that don’t make sense.
Sara Sheridan
Journalism is not a precise science, it's a crude art
Dan Rather
While it is never safe to affirm that the future of Physical Science has no marvels in store even more astonishing than those of the past, it seems probable that most of the grand underlying principles have been firmly established and that further advances are to be sought chiefly in the rigorous application of these principles to all the phenomena which come under our notice.
Robert S. Mulliken
It did not last: the Devil howling 'Ho, Let Einstein be,' restored the status quo.
John Collings Squire
Earlier fundamental work of Whitehead, Russell, Wittgenstein, Carnap, Whorf, etc., as well as my own attempt to use this earlier thinking as an epistemological base for psychiatric theory, led to a series of generalizations: That human verbal communication can operate and always does operate at many contrasting levels of abstraction. These range in two directions from the seemingly simple denotative level (“The cat is on the mat”). One range or set of these more abstract levels includes those explicit or implicit messages where the subject of discourse is the language. We will call these metalinguistic (for example, “The verbal sound ‘cat’ stands for any member of such and such class of objects”, or “The word, ‘cat’ has no fur and cannot scratch”). The other set of levels of abstraction we will call metacommunicative (e.g., “My telling you where to find the cat was friendly”, or “This is play”). In these, the subject of discourse is the relationship between the speakers. It will be noted that the vast majority of both metalinguistic and metacommunicative messages remain implicit; and also that, especially in the psychiatric interview, there occurs a further class of implicit messages about how metacommunicative messages of friendship and hostility are to be interpreted.
Gregory Bateson
Whereas Nature does not admit of more than three dimensions ... it may justly seem very improper to talk of a solid ... drawn into a fourth, fifth, sixth, or further dimension.
John Wallis
Columbus gave Europe a New World; [Alexander von] Humboldt made it known in its physical, material, intellectual, and moral aspects.
José Cipriano de la Luz y Caballero
This gesture is one of the motifs of modernity's turn against the principle of imitating nature, that is to say, imitating predefined morphological expectations. It is still capable of perceiving message-totalities and autonomous thing-signals when no morphologically intact figures are left - indeed, precisely then. The sense for perfection withdraws from the forms of nature - probably because nature itself is in the process of losing its ontological authority. The popularization of photography also increasingly devalues the standard views of things. As the first edition of the visible, nature comes into discredit. It can no longer assert its authority as the sender of binding messages - for reasons that ultimately come from its disenchantment through being scientifically explored and technically outdone. After this shift, 'being perfect' takes on an altered meaning: it means having something to say that is more meaningful than the chatter of conventional totalities. Now the torsos and their ilk have their turn: the hour of those forms that do not remind us of anything has come. Fragments, cripples and hybrids formulate something that cannot be conveyed by the common whole forms and happy integrities; intensity beats standard perfection.
Peter Sloterdijk
[To] mechanical progress there is apparently no end: for as in the past so in the future, each step in any direction will remove limits and bring in past barriers which have till then blocked the way in other directions; and so what for the time may appear to be a visible or practical limit will turn out to be but a bend in the road.(Opening address to the Mechanical Science Section, Meeting of the British Association, Manchester.)
Osborne Reynolds
Normal science, the activity in which most scientists inevitably spend almost all their time, is predicated on the assumption that the scientific community knows what the world is like... [It] often suppresses fundamental novelties because they are necessarily subversive of its basic commitments. Nevertheless, so long as those commitments retain an element of the arbitrary, the very nature of normal research ensures that the novelty shall not be suppressed for very long... [N]ormal science repeatedly goes astray. And when it does—when, that is, the profession can no longer evade anomalies that subvert the existing tradition of scientific practice—then begin the extraordinary investigations that lead the profession at last to a new set of commitments, a new basis for the practice of science. The extraordinary episodes in which that shift of professional commitments occurs are the ones known in this essay as scientific revolutions. They are the tradition-shattering complements to the tradition-bound activity of normal science.
Thomas Kuhn
Even if god was proved beyond doubt that he did not exist. We would still believe in him. We don't need hard facts, we need true emotions.
Bangambiki Habyarimana
There are over a million types of fish in the sea as there are flowers in all of the world's gardens. There are at least a million different types of minerals as there are species of birds or monkeys. The possible configurations of lifeforms that could be created from a single atom are infinite. There are at least a billion people on this earth, and no two faces look the same. It is very arrogant to assume that we have seen all of God's miracles.
Suzy Kassem
Science affects the average man and woman in two ways already. He or she benefits by its application driving a motor-car or omnibus instead of a horse-drawn vehicle, and being treated for disease by a doctor or surgeon rather than a witch.
J.B.S. Haldane
Doesn't it make you crazy??The thought that everything is one day, the time doesn't exist (it's an illusion), everything has happen in one day, but in different periods (I still ask my self how scientist even live?? With such thoughts, just thinking on what they know about the space and how something can eat us and how something is so powerful that is called quasar and it's other stars + that it's bigger than the sun, it's more powerful... How they even live, for god sake..What's the interesting thing to watch how one shadow it makes the moon (where is magic - I know it and I sound and I'm like a person who is spoiled), so the moon makes the shadow the big shadow on this planet, the moon can't handle the whole circle planet so it (1)
Deyth Banger
We see it [the as-yet unseen, probable new planet, Neptune] as Columbus saw America from the coast of Spain. Its movements have been felt, trembling along the far-reaching line of our analysis with a certainty hardly inferior to that of ocular demonstration.
William Herschel
This success permits us to hope that after thirty or forty years of observation on the new Planet [Neptune], we may employ it, in its turn, for the discovery of the one following it in its order of distances from the Sun. Thus, at least, we should unhappily soon fall among bodies invisible by reason of their immense distance, but whose orbits might yet be traced in a succession of ages, with the greatest exactness, by the theory of Secular Inequal
Urbain Le Verrier
It is infinitely better to transplant a heart than to bury it to be devoured by worms.
Christiaan Barnard
Evolution is an integration of matter and concomitant dissipation of motion during which the matter passes from an indefinite incoherent homogeneity to a definite coherent heterogeneity, and during which the retained motion undergoes a parallel transformation.
Herbert Spencer
Darwin's theory was received in Russia with profound sympathy. While in Western Europe it met firmly established old traditions which it had first to overcome, in Russia its appearance coincided with the awakening of our society after the Crimean War and here it immediately received the status of full citizenship and ever since has enjoyed widespread popularity.
Vladimir Onufrievich Kovalevskiĭ
One of the great commandments of science is, 'Mistrust arguments from authority'. (Scientists, being primates, and thus given to dominance hierarchies, of course do not always follow this commandment.)
Carl Sagan
Every day, hundreds of observations and experiments pour into the hopper of the scientific literature. Many of them don't have much to do with evolution - they're observations about the details of physiology, biochemistry, development, and so on - but many of them do. And every fact that has something to do with evolution confirms its truth. Every fossil that we find, every DNA molecule that we sequence, every organ system that we dissect, supports the idea that species evolved from common ancestors. Despite innumerable possible observations that could prove evolution untrue, we don't have a single one. We don't find mammals in Precambrian rocks, humans in the same layers as dinosaurs, or any other fossils out of evolutionary order. DNA sequencing supports the evolutionary relationships of species originally deduced from the fossil record. And, as natural selection predicts, we find no species with adaptations that only benefit a different species. We do find dead genes and vestigial organs, incomprehensible under the idea of special creation. Despite a million chances to be wrong, evolution always comes up right. That is as close as we can get to a scientific truth.
Jerry A. Coyne
Even today a good many distinguished minds seem unable to accept or even to understand that from a source of noise natural selection alone and unaided could have drawn all the music of the biosphere. In effect natural selection operates upon the products of chance and can feed nowhere else; but it operates in a domain of very demanding conditions, and from this domain chance is barred. It is not to chance but to these conditions that evolution owes its generally progressive course, its successive conquests, and the impression it gives of a smooth and steady unfolding.
Jacques Monod
In preparing the present volume, it has been the aim of the author to do full justice to the ample material at his command, and, where possible, to make the illustrations tell the main story to anatomists. The text of such a memoir may soon lose its interest, and belong to the past, but good figures are of permanent value. [Justifying elaborate illustrations in his monographs.]
Othniel Charles Marsh
No one is born with equality. We all come here with varying degrees of opportunities, qualities, strengths, weaknesses, IQ, etc.
Brandi L. Bates
What goes up, must come down." Well, Issac Newton's law doesn't apply to the internet. That's what people don't realize. When you put something up, as long as there is an internet there will be that same stuff. When you're a senior citizen, what you uploaded to Facebook at a high school party will still be there. Whatever you upload to the internet, no matter how strong your passwords and security are, guaranteed the government or some advertising corporation will look at what you post someday. The only law that applies to the internet is, "For every reaction, there is an equal and opposite reaction." Post a photograph and you'll get attention. Post your old scanned Kodak slides and family home movies, you'll get a nostalgia rush and you'll reunite people with better days. But post a bad thing, thinking you can go unnoticed, and you'll never be able to crawl out from underneath it.
Rebecca McNutt
The ultimate singularity is the Big Bang, which physicists believe was responsible for the birth of the universe. We are asked by science to believe that the entire universe sprang from nothingness, at a single point and for no discernible reason. This notion is the limit case for credulity. In other words, if you can believe this, you can believe anything. It is a notion that is, in fact, utterly absurd, yet terribly important. Those so-called rational assumptions flow from this initial impossible situation. Western religion has its own singularity in the form of the apocalypse, an event placed not at the beginning of the universe but at its end. This seems a more logical position than that of science. If singularities exist at all it seems easier to suppose that they might arise out of an ancient and highly complexified cosmos, such as our own, than out of a featureless and dimensionless mega-void.
Terence McKenna
Thus identified with astronomy, in proclaiming truths supposed to be hostile to Scripture, Geology has been denounced as the enemy of religion. The twin sisters of terrestrial and celestial physics have thus been joint-heirs of intolerance and persecution—unresisting victims in the crusade which ignorance and fanaticism are ever waging against science. When great truths are driven to make an appeal to reason, knowledge becomes criminal, and philosophers martyrs. Truth, however, like all moral powers, can neither be checked nor extinguished. When compressed, it but reacts the more. It crushes where it cannot expand—it burns where it is not allowed to shine. Human when originally divulged, it becomes divine when finally established. At first, the breath of a rage—at last it is the edict of a god. Endowed with such vital energy, astronomical truth has cut its way through the thick darkness of superstitious times, and, cheered by its conquests, Geology will find the same open path when it has triumphed over the less formidable obstacles of a civilized age.
David Brewster
The history of man is simply the history of slavery, of injustice and brutality, together with the means by which he has, through the dead and desolate years, slowly and painfully advanced. He has been the sport and prey of priest and king, the food of superstition and cruel might. Crowned force has governed ignorance through fear. Hypocrisy and tyranny—two vultures—have fed upon the liberties of man. From all these there has been, and is, but one means of escape—intellectual development. Upon the back of industry has been the whip. Upon the brain have been the fetters of superstition. Nothing has been left undone by the enemies of freedom. Every art and artifice, every cruelty and outrage has been practiced and perpetrated to destroy the rights of man. In this great struggle every crime has been rewarded and every virtue has been punished. Reading, writing, thinking and investigating have all been crimes.Every science has been an outcast.All the altars and all the thrones united to arrest the forward march of the human race. The king said that mankind must not work for themselves. The priest said that mankind must not think for themselves. One forged chains for the hands, the other for the soul. Under this infamous regime the eagle of the human intellect was for ages a slimy serpent of hypo
Robert G. Ingersoll
The sciences are not sectarian. People do not persecute each other on account of disagreements in mathematics. Families are not divided about botany, and astronomy does not even tend to make a man hate his father and mother. It is what people do not know, that they persecute each other about. Science will bring, not a sword, but peace.
Robert G. Ingersoll
Science is rooted in the will to truth. With the will to truth it stands or falls. Lower the standard even slightly and science becomes diseased at the core. Not only science, but man. The will to truth, pure and unadulterated, is among the essential conditions of his existence; if the standard is compromised he easily becomes a kind of tragic caricature of himself.
Max Wertheimer
We believe that information is an enlightening agent, but I can assure you it is not. We consume information, but we can’t read. We forgot how to sit down and engage the dense layers of a text. We are so busy devouring information that we forgot how to dance with ideas. We confuse linguistic bits of data for knowledge and ideas. I can assure you, gentlemen, they are not the same. Ideas require effort and the kind of sensibility that engages the subtle layers of meaning. What the hell does information require?
R.F. Georgy
You have to think if we've been visited by extraterrestrial life, it was like a zookeeper walking into the chimp enclosure: He looks around, takes some pictures, then leaves without interacting significantly with the environment. Meanwhile the chimps have no idea what the fuck just happened.
J. Richard Singleton
Myths grew from the ancient tradition of passing on knowledge orally, the only means of doing so before writing.They’re narratives of human existence. They helped our ancestors interpret reality, solve problems, and guided social behavior. They structured natural and social information into patterns using symbols, and embedded fact into story form. This increased their impact, making information meaningful and personally involving—not just cold, detached facts.
Alan Joshua
To me, science is an expression of the human spirit, which reaches every sphere of human culture. It gives an aim and meaning to existence as well as a knowledge, understanding, love, and admiration for the world. It gives a deeper meaning to morality and another dimension to esthetics.
Isidor Isaac Rabi
[Mathematics] is security. Certainty. Truth. Beauty. Insight. Structure. Architecture. I see mathematics, the part of human knowledge that I call mathematics, as one thing—one great, glorious thing. Whether it is differential topology, or functional analysis, or homological algebra, it is all one thing. ... They are intimately interconnected, they are all facets of the same thing. That interconnection, that architecture, is secure truth and is beauty. That's what mathematics is to me.
Paul R. Halmos
Not only in antiquity but in our own times also laws have been passed...to secure good conditions for workers; so it is right that the art of medicine should contribute its portion for the benefit and relief of those for whom the law has shown such foresight...[We] ought to show peculiar zeal...in taking precautions for their safety. I for one have done all that lay in my power, and have not thought it beneath me to step into workshops of the meaner sort now and again and study the obscure operations of mechanical arts.
Bernardino Ramazzini
An Asetian never tries to talk louder than the crowd surrounding him. An Asetian becomes that crowd.
Luis Marques
Sometimes the dim veil between sanity and insanity is perception.
Luis Marques
Do not judge others, without first judging yourself. There is no strength without knowing thyself. ☥
Luis Marques
Without risks my friends there is no progress, no advancement either in science or technology.
Sunday Adelaja
Never question the conviction of a scientist, based on mere scriptures.
Abhijit Naskar
John Dalton's records, carefully preserved for a century, were destroyed during the World War II bombing of Manchester. It is not only the living who are killed in war.
Isaac Asimov
The scientist believes in proof without certainty, the bigot in certainty without proof.
Ashley Montagu
Professor Smith has kindly submitted his book to me before publication. After reading it thoroughly and with intense interest I am glad to comply with his request to give him my impression.The work is a broadly conceived attempt to portray man's fear-induced animistic and mythic ideas with all their far-flung transformations and interrelations. It relates the impact of these phantasmagorias on human destiny and the causal relationships by which they have become crystallized into organized religion.This is a biologist speaking, whose scientific training has disciplined him in a grim objectivity rarely found in the pure historian. This objectivity has not, however, hindered him from emphasizing the boundless suffering which, in its end results, this mythic thought has brought upon man.Professor Smith envisages as a redeeming force, training in objective observation of all that is available for immediate perception and in the interpretation of facts without preconceived ideas. In his view, only if every individual strives for truth can humanity attain a happier future; the atavisms in each of us that stand in the way of a friendlier destiny can only thus be rendered ineffective.His historical picture closes with the end of the nineteenth century, and with good reason. By that time it seemed that the influence of these mythic, authoritatively anchored forces which can be denoted as religious, had been reduced to a tolerable level in spite of all the persisting inertia and hypocrisy.Even then, a new branch of mythic thought had already grown strong, one not religious in nature but no less perilous to mankind -- exaggerated nationalism. Half a century has shown that this new adversary is so strong that it places in question man's very survival. It is too early for the present-day historian to write about this problem, but it is to be hoped that one will survive who can undertake the task at a later date.
Albert Einstein
A time will come when men will stretch out their eyes. They should see planets like our Earth.
Christopher Wren
The cost of electrons and photons is getting cheaper all the time!
T. Gilling
The humanitarian philosophies that have been developed (sometimes under some religious banner and invariably in the face of religious opposition) are human inventions, as the name implies - and our species deserves the credit. I am a devout atheist - nothing else makes any sense to me and I must admit to being bewildered by those, who in the face of what appears so obvious, still believe in a mystical creator. However I can see that the promise of infinite immortality is a more palatable proposition than the absolute certainty of finite mortality which those of us who are subject to free thought (as opposed to free will) have to look forward to and many may not have the strength of character to accept it.Thus I am a supporter of Amnesty International, a humanist and an atheist. I believe in a secular, democratic society in which women and men have total equality, and individuals can pursue their lives as they wish, free of constraints - religious or otherwise. I feel that the difficult ethical and social problems which invariably arise must be solved, as best they can, by discussion and am opposed to the crude simplistic application of dogmatic rules invented in past millennia and ascribed to a plethora of mystical creators - or the latest invention; a single creator masquerading under a plethora of pseudonyms. Organisations which seek political influence by co-ordinated effort disturb me and thus I believe religious and related pressure groups which operate in this way are acting antidemocratically and should play no part in politics. I also have problems with those who preach racist and related ideologies which seem almost indistinguishable from nationalism, patriotism and religious conviction.
Harry W. Kroto
I shall not commit the fashionable stupidity of regarding everything I cannot explain as a fraud. ”—Psychiatrist Dr. Carl Jung in a 1919 address to the Society for Psychical Research in England
C.G. Jung
This is when the pill became widely known as The Pill, perhaps the only product in American history so powerful that it needed no name. Women went to their doctors and said they wanted it. They wanted The Pill. Some of them might still have been uncomfortable talking about birth control. Others might have been unsure of its brand name. But The Pill was The Pill because it was the only one that mattered, the one everyone was talking about, the one they needed.
Jonathan Eig
How have people come to be taken in by The Phenomenon of Man? We must not underestimate the size of the market for works of this kind [pseudoscience/'woo'], for philosophy-fiction. Just as compulsory primary education created a market catered for by cheap dailies and weeklies, so the spread of secondary and latterly tertiary education has created a large population of people, often with well-developed literary and scholarly tastes, who have been educated far beyond their capacity to undertake analytical thought.
Peter Medawar
No one is an outside observer of nature,We're defined by our environment and our interaction with that environment -- by our ecology. And that ecology is necessarily relative, historical and empirical.
Beau Lotto
Conventional wisdom nor scientific, mathematical prove of randomness in life could do nothing to deter human's curiosity for the unknown, however small the chance of a positive outcome maybe.
Vann Chow
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