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My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.
Jack W. Szostak
I am above the forest region, amongst grand rocks & such a torrent as you see in Salvator Rosa's paintings vegetation all a scrub of rhodos. with Pines below me as thick & bad to get through as our Fuegian Fagi on the hill tops, & except the towering peaks of P. S. [perpetual snow] that, here shoot up on all hands there is little difference in the mt scenery—here however the blaze of Rhod. flowers and various colored jungle proclaims a differently constituted region in a naturalist's eye & twenty species here, to one there, always are asking me the vexed question, where do we come from?[Letter to Charles Darwin 24 Jun 1849]
Joseph Dalton Hooker
The outgroup is rocks.
Joseph Felsenstein
An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
Francis Crick
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