Nobel Laureate Quotes

In science there is and will remain a Platonic element which could not be taken away without ruining it. Among the infinite diversity of singular phenomena science can only look for invariants.

Jacques Monod

Authority in science exists to be questioned, since heresy is the spring from which new ideas flow.

John C. Polanyi

Cosmology is a science which has only a few observable facts to work with.

Robert Woodrow Wilson

Except for the rare cases of plastid inheritance, the inheritance of all known cofactors can be sufficiently accounted for by the presence of genes in the chromosomes. In a word the cytoplasm may be ignored genetically.

Thomas Hunt Morgan

My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.

Jack W. Szostak

In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by [Frederick] Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures.[Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips]

John Kendrew

A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.

Frederick Sanger

It would be pleasant to believe that the age of pessimism is now coming to a close, and that its end is marked by the same author who marked its beginning: Aldous Huxley. After thirty years of trying to find salvation in mysticism, and assimilating the Wisdom of the East, Huxley published in 1962 a new constructive utopia, The Island. In this beautiful book he created a grand synthesis between the science of the West and the Wisdom of the East, with the same exceptional intellectual power which he displayed in his Brave New World. (His gaminerie is also unimpaired; his close union of eschatology and scatology will not be to everybody's tastes.) But though his Utopia is constructive, it is not optimistic; in the end his island Utopia is destroyed by the sort of adolescent gangster nationalism which he knows so well, and describes only too convincingly.This, in a nutshell, is the history of thought about the future since Victorian days. To sum up the situation, the sceptics and the pessimists have taken man into account as a whole; the optimists only as a producer and consumer of goods. The means of destruction have developed pari passu with the technology of production, while creative imagination has not kept pace with either.The creative imagination I am talking of works on two levels. The first is the level of social engineering, the second is the level of vision. In my view both have lagged behind technology, especially in the highly advanced Western countries, and both constitute dangers.

Dennis Gabor

Littlewood, on Hardy's own estimate, is the finest mathematician he has ever known. He was the man most likely to storm and smash a really deep and formidable problem; there was no one else who could command such a combination of insight, technique and power.

Henry Hallett Dale

One can still say that quantum mechanics is the key to understanding magnetism. When one enters the first room with this key there are unexpected rooms beyond, but it is always the master key that unlocks each door.

John H. Van Vleck

Will fluorine ever have practical applications?It is very difficult to answer this question. I may, however, say in all sincerity that I gave this subject little thought when I undertook my researches, and I believe that all the chemists whose attempts preceded mine gave it no more consideration.A scientific research is a search after truth, and it is only after discovery that the question of applicability can be usefully considered.

Henri Moissan

[In the case of research director, Willis R. Whitney, whose style was to give talented investigators as much freedom as possible, you may define 'serendipity' as] the art of profiting from unexpected occurrences. When you do things in that way you get unexpected results. Then you do something else and you get unexpected results in another line, and you do that on a third line and then all of a sudden you see that one of these lines has something to do with the other. Then you make a discovery that you never could have made by going on a direct road.

Irving Langmuir

The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.

Max F. Perutz

A famous name has this peculiarity that it becomes gradually smaller especially in natural sciences where each succeeding discovery invariably overshadows what precedes.

Jacobus Henricus van 't Hoff

During this time (at high school) I discovered the Public Library... It was here that I found a source of knowledge and the means to acquire it by reading, a habit of learning which I still follow to this day. I also became interested in chemistry and gradually accumulated enough test tubes and other glassware to do chemical experiments, using small quantities of chemicals purchased from a pharmacy supply house. I soon graduated to biochemistry and tried to discover what gave flowers their distinctive colours. I made the (to me) astounding discovery that the pigments I extracted changed their colours when I changed the pH of the solution.

Sydney Brenner

It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.

Alexander Fleming

I had fallen in love with a young man..., and we were planning to get married. And then he died of subacute bacterial endocarditis... Two years later with the advent of penicillin, he would have been saved. It reinforced in my mind the importance of scientific discovery...

Gertrude B. Elion

I would not be among you to-night (being awarded the 1964 Nobel Prize in Physiology or Medicine) but for the mentors, colleagues and students who have guided and aided me throughout my scientific life. I wish I could name them all and tell you their contributions. More, however, than anyone else it was the late Rudolf Schoenheimer, a brilliant scholar and a man of infectious enthusiasm, who introduced me to the wonders of Biochemistry. Ever since, I have been happy to have chosen science as my career, and, to borrow a phrase of Jacques Barzun, have felt that 'Science is, in the best and strictest sense, glorious entertainment'.

Konrad Bloch

It is because I know all that science can bring to the world that I shall continue my efforts to ensure that it contributes to the happiness of all men, whether they be white, black, or yellow, and not to their annihilation in the name of some divine mission or other.

Frédéric Joliot-Curie

Individual events. Events beyond law. Events so numerous and so uncoordinated that, flaunting their freedom from formula, they yet fabricate firm form.

John Archibald Wheeler

I studied calculus for the first time, which to me was an amazingly empowering experience which I could really see how you could understand all sorts of things, and I decided that chemistry and biology just had too much memory for me to be interested. Physics was very easy.

Marshall Nicholas Rosenbluth

The history of atomism is one of reductionism – the effort to reduce all the operations of nature to a small number of laws governing a small number of primordial objects.

Leon M. Lederman

If a problem is clearly stated, it has no further interest to the physicist.

Peter Debye

Since the beginning of physics, symmetry considerations have provided us with an extremely powerful and useful tool in our effort to understand nature. Gradually they have become the backbone of our theoretical formulation of physical laws.

Tsung-Dao Lee

The answer to the ancient question 'Why is there something rather than nothing?' would then be that ‘nothing’ is unstable.

Frank Wilczek

If we ascribe the ejection of the proton to a Compton recoil from a quantum of 52 x 106 electron volts, then the nitrogen recoil atom arising by a similar process should have an energy not greater than about 400,000 volts, should produce not more than about 10,000 ions, and have a range in the air at N.T.P. of about 1-3mm. Actually, some of the recoil atoms in nitrogen produce at least 30,000 ions. In collaboration with Dr. Feather, I have observed the recoil atoms in an expansion chamber, and their range, estimated visually, was sometimes as much as 3mm. at N.T.P.These results, and others I have obtained in the course of the work, are very difficult to explain on the assumption that the radiation from beryllium is a quantum radiation, if energy and momentum are to be conserved in the collisions. The difficulties disappear, however, if it be assumed that the radiation consists of particles of mass 1 and charge 0, or neutrons. The capture of the a-particle by the Be9 nucleus may be supposed to result in the formation of a C12 nucleus and the emission of the neutron. From the energy relations of this process the velocity of the neutron emitted in the forward direction may well be about 3 x 109 cm. per sec. The collisions of this neutron with the atoms through which it passes give rise to the recoil atoms, and the observed energies of the recoil atoms are in fair agreement with this view. Moreover, I have observed that the protons ejected from hydrogen by the radiation emitted in the opposite direction to that of the exciting a-particle appear to have a much smaller range than those ejected by the forward radiation.This again receives a simple explanation on the neutron hypothesis.

James Chadwick

Tapestries are made by many artisans working together. The contributions of separate workers cannot be discerned in the completed work, and the loose and false threads have been covered over. So it is in our picture of particle physics.

Sheldon L. Glashow

It has today occurred to me that an amplifier using semiconductors rather than vacuum is in principle possible.[Laboratory notebook, 29 Dec 1939.]

William Shockley

If my efforts have led to greater success than usual, this is due, I believe, to the fact that during my wanderings in the field of medicine, I have strayed onto paths where the gold was still lying by the wayside. It takes a little luck to be able to distinguish gold from dross, but that is all.

Robert Koch

[Concerning] phosphorescent bodies, and in particular to uranium salts whose phosphorescence has a very brief duration. With the double sulfate of uranium and potassium ... I was able to perform the following experiment: One wraps a Lumière photographic plate with a bromide emulsion in two sheets of very thick black paper, such that the plate does not become clouded upon being exposed to the sun for a day. One places on the sheet of paper, on the outside, a slab of the phosphorescent substance, and one exposes the whole to the sun for several hours. When one then develops the photographic plate, one recognizes that the silhouette of the phosphorescent substance appears in black on the negative. If one places between the phosphorescent substance and the paper a piece of money or a metal screen pierced with a cut-out design, one sees the image of these objects appear on the negative. One can repeat the same experiments placing a thin pane of glass between the phosphorescent substance and the paper, which excludes the possibility of chemical action due to vapors which might emanate from the substance when heated by the sun's rays. One must conclude from these experiments that the phosphorescent substance in question emits rays which pass through the opaque paper and reduces silver

Henri Becquerel

We may fondly imagine that we are impartial seekers after truth, but with a few exceptions, to which I know that I do not belong, we are influenced—and sometimes strongly—by our personal bias; and we give our best thoughts to those ideas which we have to defend.

August Krogh

While it is never safe to affirm that the future of Physical Science has no marvels in store even more astonishing than those of the past, it seems probable that most of the grand underlying principles have been firmly established and that further advances are to be sought chiefly in the rigorous application of these principles to all the phenomena which come under our notice.

Robert S. Mulliken

I should like to preface my remarks with a personal statement in order that my later remarks will not be misunderstood. I consider myself an atheist.

Subrahmanijan Chandrasekhar

I would like to start by emphasizing the importance of surfaces. It is at a surface where many of our most interesting and useful phenomena occur. We live for example on the surface of a planet. It is at a surface where the catalysis of chemical reactions occur. It is essentially at a surface of a plant that sunlight is converted to a sugar. In electronics, most if not all active circuit elements involve non-equilibrium phenomena occurring at surfaces. Much of biology is concerned with reactions at a surface.

Walter Houser Brattain

Scientific truth is universal, because it is only discovered by the human brain and not made by it, as art is.

Konrad Lorenz

I have no doubt that we will be successful in harnessing the sun's energy. ... If sunbeams were weapons of war, we would have had solar energy centuries ago.

George Porter

In some strange way, any new fact or insight that I may have found has not seemed to me as a “discovery” of mine, but rather something that had always been there and that I had chanced to pick up.

Subrahmanijan Chandrasekhar

Nature creates curved lines while humans create straight lines.

Hideki Yukawa

The zoologist is delighted by the differences between animals, whereas the physiologist would like all animals to work in fundamentally the same way.

Alan Hodgkin

As was the case for Nobel's own invention of dynamite, the uses that are made of increased knowledge can serve both beneficial and potentially harmful ends. Increased knowledge clearly implies increased responsibility.

Nicolaas Bloembergen

A recognized fact which goes back to the earliest times is that every living organism is not the sum of a multitude of unitary processes, but is, by virtue of interrelationships and of higher and lower levels of control, an unbroken unity. When research, in the efforts of bringing understanding, as a rule examines isolated processes and studies them, these must of necessity be removed from their context. In general, viewed biologically, this experimental separation involves a sacrifice. In fact, quantitative findings of any material and energy changes preserve their full context only through their being seen and understood as parts of a natural order.

Walter Rudolf Hess

If the militarily most powerful and least threatened states need nuclear weapons for their security, how can one deny such security to countries that are truly insecure? The present nuclear policy is a recipe for proliferation. It is a policy for disaster.

Joseph Rotblat

Perhaps the most impressive illustration of all is to suppose that you could label the molecules in a tumbler of water. ... threw it anywhere you please on the earth, and went away from the earth for a few million years while all the water on the earth, the oceans, rivers, lakes and clouds had had time to mix up perfectly. Now supposing that perfect mixing had taken place, you come back to earth and draw a similar tumbler of water from the nearest tap, how many of those marked molecules would you expect to find in it? Well, the answer is 2000. There are 2000 times more molecules in a tumbler of water than there are tumblers of water in the whole earth.

Francis William Aston

The atom can't be seen, yet its existence can be proved. And it is simple to prove that it can't ever be seen. It has to be studied by indirect evidence — and the technical difficulty has been compared to asking a man who has never seen a piano to describe a piano from the sound it would make falling downstairs in the dark.

Carl David Anderson

I have a friend — or had a friend, now dead — Abdus Salam, a very devout Muslim, who was trying to bring science into the universities in the Gulf states and he told me that he had a terrible time because, although they were very receptive to technology, they felt that science would be a corrosive to religious belief, and they were worried about it… and damn it, I think they were right. It is corrosive of religious belief, and it’s a good thing too.

Steven Weinberg

Nature seems to take advantage of the simple mathematical representations of the symmetry laws. When one pauses to consider the elegance and the beautiful perfection of the mathematical reasoning involved and contrast it with the complex and far-reaching physical consequences, a deep sense of respect for the power of the symmetry laws never fails to develop.

Chen Ning Yang

I might paraphrase Churchill and say: never have I received so much for so little.[Exemplifying humility, upon accepting the Nobel Prize in Chemistry.]

Luis Federico Leloir

It is essential for genetic material to be able to make exact copies of itself; otherwise growth would produce disorder, life could not originate, and favourable forms would not be perpetuated by natural selection.

Maurice Wilkins

The fundamental biological variant is DNA. That is why Mendel's definition of the gene as the unvarying bearer of hereditary traits, its chemical identification by Avery (confirmed by Hershey), and the elucidation by Watson and Crick of the structural basis of its replicative invariance, are without any doubt the most important discoveries ever made in biology. To this must be added the theory of natural selection, whose certainty and full significance were established only by those later theories.

Jacques Monod

I looked for it [heavy hydrogen, deuterium] because I thought it should exist. I didn't know it would have industrial applications or be the basic for the most powerful weapon ever known [the nuclear bomb] ... I thought maybe my discovery might have the practical value of, say, neon in neon s

Harold Urey

[Pure research] is worth every penny it costs.

Harold Urey

I am an atheist.

Hans Bethe

I am not religious in any sense; in fact, I consider myself an atheist.

Subrahmanijan Chandrasekhar

But every day I go to work I'm making a bet that the universe is simple, symmetric, and aesthetically pleasing—a universe that we humans, with our limited perspective, will someday understand.

George Smoot

I think that the event which, more than anything else, led me to the search for ways of making more powerful radio telescopes, was the recognition, in 1952, that the intense source in the constellation of Cygnus was a distant galaxy—1000 million light years away. This discovery showed that some galaxies were capable of producing radio emission about a million times more intense than that from our own Galaxy or the Andromeda nebula, and the mechanisms responsible were quite unknown. ... [T]he possibilities were so exciting even in 1952 that my colleagues and I set about the task of designing instruments capable of extending the observations to weaker and weaker sources, and of exploring their internal structure.

Martin Ryle

...the scientific attitude implies what I call the postulate of objectivity—that is to say, the fundamental postulate that there is no plan, that there is no intention in the universe. Now, this is basically incompatible with virtually all the religious or metaphysical systems whatever, all of which try to show that there is some sort of harmony between man and the universe and that man is a product—predictable if not indispensable—of the evolution of the universe.

Jacques Monod

The progress of science has always been the result of a close interplay between our concepts of the universe and our observations on nature. The former can only evolve out of the latter and yet the latter is also conditioned greatly by the former. Thus in our exploration of nature, the interplay between our concepts and our observations may sometimes lead to totally unexpected aspects among already familiar phenomena.

Tsung-Dao Lee

From the age of 13, I was attracted to physics and mathematics. My interest in these subjects derived mostly from popular science books that I read avidly. Early on I was fascinated by theoretical physics and determined to become a theoretical physicist. I had no real idea what that meant, but it seemed incredibly exciting to spend one's life attempting to find the secrets of the universe by using one's mind.

David Gross

[My study of the universe] leaves little doubt that life has occurred on other planets. I doubt if the human race is the most intelligent form of life.

Harold Urey

I’m now ‘Doctor’ to the patients and I have to cover my ignorance by waving my arms and looking grave.

Howard Florey

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Nobel Laureate Quotes

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