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My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.
Jack W. Szostak
There are no mineral monsters.
Canguilhem
A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
Frederick Sanger
People, as curious primates, dote on concrete objects that can be seen and fondled. God dwells among the details, not in the realm of pure generality. We must tackle and grasp the larger, encompassing themes of our universe, but we make our best approach through small curiosities that rivet our attention - all those pretty pebbles on the shoreline of knowledge. For the ocean of truth washes over the pebbles with every wave, and they rattle and clink with the most wondrous din.
Stephen Jay Gould
Biologists will teach us that the survival of the species depends on cooperation, not competition.
Robert Holden
Oxygen deprivation and supplemental oxygen are both bio-hazards for Mauna Kea workers
Steven Magee
Very high altitude astronomy only works by ignoring established biological science
Steven Magee
Water is one of the least understood aspects of biology.
Steven Magee
The attention given to the side of the head which has received the injury, in connection with a specific reference to the side of the body nervously affected, is in itself evidence that in this case the ancient surgeon was already beginning observations on the localization of functions in the brain.
James Henry Breasted
A multitude of harlequin lifeforms bobbed and twirled and played in the depths of the Atlantic. Pink cucumbers with thorny backs. Algae. Starfish. Annelids with simple brains and a hundred toes. Sponges—like yellow, swollen hands—sucked in water and pushed out oxygen. Most amusing were the mysterious buggers who had no likeness on the previous earth; tiny beasts with exotic exoskeletons engraved with deep grid-like patterns, snails with horns, and slithering plants that looked like magenta weeping willows.
Jake Vander-Ark
When I realized that my home was completely filled with a biologically toxic radio wave field, I decided that the best route forward was to milk the home for all of the biological research that I could possibly produce from it!
Steven Magee
Natural selection is not the wind which propels the vessel, but the rudder which, by friction, now on this side and now on that, shapes the course.
Asa Gray
Evolution is an integration of matter and concomitant dissipation of motion during which the matter passes from an indefinite incoherent homogeneity to a definite coherent heterogeneity, and during which the retained motion undergoes a parallel transformation.
Herbert Spencer
Darwin's theory was received in Russia with profound sympathy. While in Western Europe it met firmly established old traditions which it had first to overcome, in Russia its appearance coincided with the awakening of our society after the Crimean War and here it immediately received the status of full citizenship and ever since has enjoyed widespread popularity.
Vladimir Onufrievich Kovalevskiĭ
Living organisms were not independently created, but have descended and diversified over time from common ancestors. And thus, no other biological theory so elegantly explains this. Evolutionary theory has withstood the test of time—by way of vicarious experimentation, observation, analysis, and relentless criticism, though opposing viewpoints still cling to the concept of "design." As a person of the biological sciences, I cannot subscribe to such misguided notions that suggest static biological states. Clearly, proper examination of the natural world reveal evolutionary trajectories—some random, others nonrandom—and all having observable genetic implications. It is only when we apply evolutionary explanations to living systems that it becomes ever so clear. The world was not specifically designed with us in mind, but rather we long since adapted and conformed to our surroundings, only giving it the illusionary appearance of "design.
Tommy Rodriguez
Every day, hundreds of observations and experiments pour into the hopper of the scientific literature. Many of them don't have much to do with evolution - they're observations about the details of physiology, biochemistry, development, and so on - but many of them do. And every fact that has something to do with evolution confirms its truth. Every fossil that we find, every DNA molecule that we sequence, every organ system that we dissect, supports the idea that species evolved from common ancestors. Despite innumerable possible observations that could prove evolution untrue, we don't have a single one. We don't find mammals in Precambrian rocks, humans in the same layers as dinosaurs, or any other fossils out of evolutionary order. DNA sequencing supports the evolutionary relationships of species originally deduced from the fossil record. And, as natural selection predicts, we find no species with adaptations that only benefit a different species. We do find dead genes and vestigial organs, incomprehensible under the idea of special creation. Despite a million chances to be wrong, evolution always comes up right. That is as close as we can get to a scientific truth.
Jerry A. Coyne
Even today a good many distinguished minds seem unable to accept or even to understand that from a source of noise natural selection alone and unaided could have drawn all the music of the biosphere. In effect natural selection operates upon the products of chance and can feed nowhere else; but it operates in a domain of very demanding conditions, and from this domain chance is barred. It is not to chance but to these conditions that evolution owes its generally progressive course, its successive conquests, and the impression it gives of a smooth and steady unfolding.
Jacques Monod
Man is a product of nature, a part of the Universe. The Universe is operated under exact natural laws. Man is a product of millions of years of evolution. He adapts himself to the laws of nature or he perishes.
James Hervey Johnson
Not only in antiquity but in our own times also laws have been passed...to secure good conditions for workers; so it is right that the art of medicine should contribute its portion for the benefit and relief of those for whom the law has shown such foresight...[We] ought to show peculiar zeal...in taking precautions for their safety. I for one have done all that lay in my power, and have not thought it beneath me to step into workshops of the meaner sort now and again and study the obscure operations of mechanical arts.
Bernardino Ramazzini
She had a theory that the fear of getting in trouble was what made her not as good a programmer and that, in fact, it was all linked to testosterone, and that was why there were more guy programmers than women. It was a very hazy theory, and she didn't like it, but she had pretty much convinced herself it was true, although she couldn't bear to think of sharing it with anybody, because it was a lot better to think that there were social reasons why girls didn't usually become code monkeys than to think there were biological reasons.
Maureen F. McHugh
When Mother Nature speaks, even the Gods hold silence.
Abhijit Naskar
I wanted to present Neuroscience to people in a way that would diminish their differences.
Abhijit Naskar
I don't believe any scientific field to be superior to another.
Abhijit Naskar
Quick dinner with ... Ang [Lee] and his wife Jane who's visiting with the children for a while. We talked about her work as a microbiologist and the behaviour of the epithingalingie under the influence of cholesterol. She's fascinated by cholesterol. Says it's very beautiful: bright yellow. She says Ang is wholly uninterested. He has no idea what she does.I check this out for myself. 'What does Jane do?' I ask.'Science,' he says vaguely.
Emma Thompson
I like to define biology as the history of the earth and all its life — past, present, and future. To understand biology is to understand that all life is linked to the earth from which it came; it is to understand that the stream of life, flowing out of the dim past into the uncertain future, is in reality a unified force, though composed of an infinite number and variety of separate lives.
Rachel Carson
The information contained in an English sentence or computer software does not derive from the chemistry of the ink or the physics of magnetism, but from a source extrinsic to physics and chemistry altogether. Indeed, in both cases, the message transcends the properties of the medium. The information in DNA also transcends the properties of its material medium.
Stephen C. Meyer
Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.
Michael Denton
If Darwinists are opposed to mentioning scientific problems with their view, you would think they would be even more opposed to mentioning intelligent design. Yet Darwinists have been discussing ID in public school science classes for years... Biology textbooks have been mentioning intelligent design since the late 1990s—but only to misrepresent and disparage it.
Jonathan Wells
The phrase 'the fossil record' sounds impressive and authoritative. As used by some persons it becomes, as intended, intimidating, taking on the aura of esoteric truth as expounded by an elite class of specialists. But what is it, really, this fossil record? Only data in search of interpretation. All claims to the contrary that I know, and I know of several, are so much superstition.
Gareth J. Nelson
The most essential prediction of Darwinism is that, given an astronomical number of chances, unintelligent processes can make seemingly-designed systems, ones of the complexity of those found in the cell. ID specifically denies this, predicting that in the absence of intelligent input no such systems would develop. So Darwinism and ID make clear, opposite predictions of what we should find when we examine genetic results from a stupendous number of organisms that are under relentless pressure from natural selection. The recent genetic results are a stringent test. The results: 1) Darwinism’s prediction is falsified; 2) Design’s prediction is confirmed.
Michael J. Behe
Sorgan tried his very best not to think about how long it must have taken for a stream that small to eat its way down through solid rock to form its current bed. Sorgan knew exactly what the word “hundred” meant, but when numbers wandered off toward “thousand”—or even “million”—and the people who used those terms were talking about years, Sorgan’s mind shied back in horror.
David Eddings
I don't believe any scientific field to be superior to another.
Abhijit Naskar
Quick dinner with ... Ang [Lee] and his wife Jane who's visiting with the children for a while. We talked about her work as a microbiologist and the behaviour of the epithingalingie under the influence of cholesterol. She's fascinated by cholesterol. Says it's very beautiful: bright yellow. She says Ang is wholly uninterested. He has no idea what she does.I check this out for myself. 'What does Jane do?' I ask.'Science,' he says vaguely.
Emma Thompson
Thus, by science I mean, first of all, a worldview giving primacy to reason and observation and a methodology aimed at acquiring accurate knowledge of the natural and social world. This methodology is characterized, above all else, by the critical spirit: namely, the commitment to the incessant testing of assertions through observations and/or experiments — the more stringent the tests, the better — and to revising or discarding those theories that fail the test. One corollary of the critical spirit is fallibilism: namely, the understanding that all our empirical knowledge is tentative, incomplete and open to revision in the light of new evidence or cogent new arguments (though, of course, the most well-established aspects of scientific knowledge are unlikely to be discarded entirely).. . . I stress that my use of the term 'science' is not limited to the natural sciences, but includes investigations aimed at acquiring accurate knowledge of factual matters relating to any aspect of the world by using rational empirical methods analogous to those employed in the natural sciences. (Please note the limitation to questions of fact. I intentionally exclude from my purview questions of ethics, aesthetics, ultimate purpose, and so forth.) Thus, 'science' (as I use the term) is routinely practiced not only by physicists, chemists and biologists, but also by historians, detectives, plumbers and indeed all human beings in (some aspects of) our daily lives. (Of course, the fact that we all practice science from time to time does not mean that we all practice it equally well, or that we practice it equally well in all areas of our lives.)
Alan Sokal
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