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The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.
Max F. Perutz
Eh bien, then, you are crazy, or appear crazy or you think you are crazy, and possibly you may be crazy.
Agatha Christie
But when you say crazy, that describes very well what the general appearance may be to ordinary, everyday people.
Agatha Christie
Intuition is like reading a word without having to spell it out. A child can't do that because it has had so little experience. A grown-up person knows the word because they've seen it often before.
Agatha Christie
There is at Christmas time a great deal of hypocrisy, honourable hypocrisy, hypocrisy undertaken pour le bon motif, c'est entendu, but nevertheless hypocrisy!
Agatha Christie
History was my favourite subject at school and in my spare time I read historical novels voraciously from Heidi to the Scarlet Pimpernel and from Georgette Heyer to Agatha Christie.
Sara Sheridan
Alma didn’t want Isabel to start singing the praises of their pet, a rescue beagle, or she wouldn’t shush until sundown. “I’ve found the missing lady,” Alma said. “Say welcome home, Betsy Sweet.
Ed Lynskey
There is something about the defencelessness of youth that moves me to tears. Youth is so vulnerable. It is so ruthless--so sure. So generous and so demanding.
Agatha Christie
It is the courage, the insistence, the ruthless force of youth.
Agatha Christie
The two words expressed volumes.
Agatha Christie
Your idea of a woman is someone who gets on a chair and shrieks if she sees a mouse. That's all prehistoric.
Agatha Christie
What a queer topsy turvy world it was. It used to be the man who went to the wars, the woman who stayed at home. But here the positions were reversed.
Agatha Christie
Sensationalism dies quickly, fear is long-lived.
Agatha Christie
When you think about the period in which Agatha Christie's crime novels were written, they are actually quite edgy for the time.
Sara Sheridan
You don't appreciate a faithful husband when you've got one,' said Tommy.'All my friends tell me you never know with husbands,' said Tuppance.'You have the wrong kind of friends,' said Tommy.
Agatha Christie
Use that fluff of yours you call a brain.
Agatha Christie
You don't appreciate a faithful husband when you've got one,' said Tommy.'All my friends tell me you never know with husbands,' said Tuppance.'You have the wrong kind of friends,' said Tommy.
Agatha Christie
Use that fluff of yours you call a brain.
Agatha Christie
Even though I'm an ordinary writer, I too, have trouble when it come to writing along the way. But at least I manage to self-publish my book with no errors (hopefully). Just check out Agatha Christie, an author who also has a learning disability. She managed to be succesful. And I hope that I would be successful as her and Abishek Bachan.
Simi Sunny
Poetry is not the most important thing in life... I'd much rather lie in a hot bath reading Agatha Christie and sucking sweets.
Dylan Thomas
And yet," said Poirot, "suppose an accident-""Ah, no, my friend-""From your point of view it would be regrettable, I agree. But nevertheless let us just for one moment suppose it. Then, perhaps, all these here are linked together - by death.
Agatha Christie
La vie est vaine,Un peu d’amour,Un peu de haine,Et puis—Bonjour!La vie est brève:Un peu d’espoir,Un peu de rèveEt puis—Bon soir! Ah, brief is Life,Love’s short sweet way,With dreamings rife,And then—Good-day!And Life is vain—Hope’s vague delight,Grief’s transient pain,And then—Good-night.
George du Maurie
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