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Quotes by Molecular Biologists
Whenever you fall pick something up.
Oswald Avery
If the results of the present study on the chemical nature of the transforming principle are confirmed, then nucleic acids must be regarded as possessing biological specificity the chemical basis of which is as yet undetermined.
Oswald Theodore Avery
The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.
Max F. Perutz
We are at the dawn of a new era, the era of 'molecular biology' as I like to call it, and there is an urgency about the need for more intensive application of physics and chemistry, and specially of structure analysis, that is still not sufficiently appreciated.
William Astbury
Science and religion have in common the aim of seeking and achieving unity. Most scientists today are being led increasingly away from the fundamental aim of science to achieve unity into rather limited ways of thinking without much open-mindedness, doing things merely to meet limited material needs.
Maurice Wilkins
An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
Francis Crick
The dangerous man is the one who has only one idea, because then he'll fight and die fo
Francis Crick
It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clicks into place. One immediately sees how many previously puzzling facts are neatly explained by the new hypothesis. One could kick oneself for not having the idea earlier, it now seems so obvious. Yet before, everything was in a fog.
Francis Crick
It is essential for genetic material to be able to make exact copies of itself; otherwise growth would produce disorder, life could not originate, and favourable forms would not be perpetuated by natural selection.
Maurice Wilkins
It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
Francis Crick
I saw [Linus Pauling] as a brilliant lecturer and a man with a fantastic memory, and a great, great showman. I think he was the century’s greatest chemist. No doubt about it.
Max F. Perutz