Quotes by Biochemists - Page 4

Despite all that education and experience can do, I retain a certain level of unsophistication that I cannot eradicate and that my friends find amusing. In fact, I think I sometimes detect conspiratorial plottings among my friends to protect me against my own lack of sophistication. I don't mind. I suspect that I am never quite as unsophisticated as they think I am, but I don't mind.
Isaac Asimov
As we began discussing authorship of a white paper summarizing our conclusions, we debated who our target audience should be and what kind of outcome we were hoping to achieve.
Jennifer A. Doudna
Agitation from the other side of the desk.“No—now you must take this phlegmatically. You had hoped you would qualify. You had feared you would not. Actually, both hope and fear are weaknesses. You knew you would qualify and you hesitate to admit the fact because such knowledge might stamp you as cocksure and therefore unfit. Nonsense! The most hopelessly stupid man is he who is not aware that he is wise. It is part of your qualification that you knew you would qualify.”Relaxation on the other side of the desk.“Exactly. Now you feel better and your guard is down. You are fitter to concentrate and fitter to understand. Remember, to be truly effective, it is not necessary to hold the mind under a tight, controlling barrier which to the intelligent probe is as informative as a naked mentality. Rather, one should cultivate an innocence, an awareness of self, and an unselfconsciousness of self which leaves one nothing to hide. My mind is open to you. Let this be so for both of us.
Isaac Asimov
I am afraid a monster is grown that will devour all of us. Yet we must fight him.
Isaac Asimov
Any book worth banning is a book worth reading.
Isaac Asimov
What I will be remembered for are the Foundation Trilogy and the Three Laws of Robotics. What I want to be remembered for is no one book, or no dozen books. Any single thing I have written can be paralleled or even surpassed by something someone else has done. However, my total corpus for quantity, quality and variety can be duplicated by no one else. That is what I want to be remembered for.
Isaac Asimov
We are gaining the knowledge science is giving us that. Now we need wisdom as well.
Isaac Asimov
It is the sense of mystery that, in my opinion, drives the true scientist; the same force, blindly seeing, deafly hearing, unconsciously remembering, that drives the larva into the butterfly. If he has not experienced, at least a few times in his life, this cold shudder down his spine, this confrontation with an immense, invisible face whose breath moves him to tears, he is not a scientist. The blacker the night, the brighter the light.
Erwin Chargaff
A planet might deteriorate even if human beings existed upon it, if the society were itself abnormal and did not understand the importance of preserving the environment.""Surely," said Pelorat, "such a society would quickly be destroyed. I don't think it would be possible for human beings to fail to understand the importance of retaining the very factors that are keeping them alive."Bliss said, "I don't have your pleasant faith in human reason, Pel. It seems to me to be quite conceivable that when a planetary society consists of Isolates, local and even individual concerns might easily by allowed to overcome planetary concerns.
Isaac Asimov
It is possible to be too stable. No Outer World has colonized a new planet in two and a half centuries.. are lives too long to risk and too comfortable to upset.“I don’t know about that, Dr. Fastolfe. You’ve come to Earth. You risk disease.”“Yes, I do. There are some of us, Mr. Baley, who feel that the future of the human race is even worth the possible loss of an extended lifetime. Too few of us, I am sorry to say.”“In trying to introduce robots here on Earth, we’re doing our best to upset the balance of your City economy.”“You mean you’re creating a growing group of displaced and declassified men on purpose?”“Not out of cruelty or callousness, believe me. A group of displaced men, as you call them, are what we need to serve as a nucleus for colonization. Your ancient America was discovered by ships fitted out with men from the prisons. Don’t you see that the City’s womb has failed the displaced man. He has nothing to lose and worlds to gain by leaving Earth.
Isaac Asimov
in 2011, Rachel and I founded a company called Caribou Biosciences to commercialize the Cas proteins.
Jennifer A. Doudna
Editas Medicine has an exclusive multimillion-dollar license with Juno Therapeutics to develop T cell therapies
Jennifer A. Doudna
PGD has also been used for other controversial purposes, such as the birth if so-called savior siblings, destined from the moment of implantation not only to live their own lives, but also to serve as organ or cell donors for a sibling.
Jennifer A. Doudna
we founded Editas Medicine with $43 million in financing from three venture capital firms.
Jennifer A. Doudna
The theory of phlogiston was an inversion of the true nature of combustion. Removing phlogiston was in reality adding oxygen, while adding phlogiston was actually removing oxygen. The theory was a total misrepresentation of reality. Phlogiston did not even exist, and yet its existence was firmly believed and the theory adhered to rigidly for nearly one hundred years throughout the eighteenth century. ... As experimentation continued the properties of phlogiston became more bizarre and contradictory. But instead of questioning the existence of this mysterious substance it was made to serve more comprehensive purposes. ... For the skeptic or indeed to anyone prepared to step out of the circle of Darwinian belief, it is not hard to find inversions of common sense in modern evolutionary thought which are strikingly reminiscent of the mental gymnastics of the phlogiston chemists or the medieval astronomers.To the skeptic, the proposition that the genetic programmes of higher organisms, consisting of something close to a thousand million bits of information, equivalent to the sequence of letters in a small library of one thousand volumes, containing in encoded form countless thousands of intricate algorithms controlling, specifying and ordering the growth and development of billions and billions of cells into the form of a complex organism, were composed by a purely random process is simply an affront to reason. But to the Darwinist the idea is accepted without a ripple of doubt - the paradigm takes precedence!
Michael Denton
I, on the other hand, am a finished product. I absorb electrical energy directly and utilize it with an almost one hundred percent efficiency. I am composed of strong metal, am continuously conscious, and can stand extremes of environment easily. These are facts which, with the self-evident proposition that no being can create another being superior to itself, smashes your silly hypothesis to nothing.
Isaac Asimov
And just how did you arrive at that remarkable conclusion, Mr. Mayor?""In a rather simple way. It merely required the use of that much-neglected commodity -- common sense. You see, there is a branch of human knowledge known as symbolic logic, which can be used to prune away all sorts of clogging deadwood that clutters up human language.""What about it?" said Fulham."I applied it. Among other things, I applied it to this document here. I didn't really need to for myself because I knew what it was all about, but I think I can explain it more easily to five physical scientists by symbols rather than by words."Hardin removed a few sheets of paper from the pad under his arm and spread them out. "I didn't do this myself, by the way," he said. "Muller Holk of the Division of Logic has his name signed to the analyses, as you can see."Pirenne leaned over the table to get a better view and Hardin continued: "The message from Anacreon was a simple problem, naturally, for the men who wrote it were men of action rather than men of words. It boils down easily and straightforwardly to the unqualified statement, when in symbols is what you see, and which in words, roughly translated is, 'You give us what we want in a week, or we take it by force.'"There was silence as the five members of the Board ran down the line of symbols, and then Pirenne sat down and coughed uneasily.Hardin said, "No loophole, is there, Dr. Pirenne?""Doesn't seem to be.
Isaac Asimov
life is either a reproducible, almost commonplace manifestation of matter, given certain conditions, or a miracle. Too many steps are involved to allow for something in between.
Christian de Duve
Real arms races are run by highly intelligent, bespectacled engineers in glass offices thoughtfully designing shiny weapons on modern computers. But there's no thinking in the mud and cold of nature's trenches. At best, weapons thrown together amidst the explosions and confusion of smoky battlefields are tiny variations on old ones, held together by chewing gum. If they don't work, then something else is thrown at the enemy, including the kitchen sink - there's nothing "progressive" about that. At its usual worst, trench warfare is fought by attrition. If the enemy can be stopped or slowed by burning your own bridges and bombing your own radio towers and oil refineries, then away they go. Darwinian trench warfare does not lead to progress - it leads back to the Stone Age.
Michael J. Behe
Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.
Michael Denton
To grasp the reality of life as it has been revealed by molecular biology, we must magnify a cell a thousand million times until it is twenty kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would then see would be an object of unparalleled complexity and adaptive design. On the surface of the cell we would see millions of openings, like the port holes of a vast space ship, opening and closing to allow a continual stream of materials to flow in and out. If we were to enter one of these openings we would find ourselves in a world of supreme technology and bewildering complexity.
Michael Denton
In the discoveries of science the harmony of the spheres is also now the harmony of life. And as the eerie illumination of science penetrates evermore deeply into the order of nature, the cosmos appears increasingly to be a vast system finely tuned to generate life and organisms of biology very similar, perhaps identical, to ourselves. All the evidence available in the biological sciences supports the core proposition of traditional natural theology - that the cosmos is a specially designed whole with life and mankind as a fundamental goal and purpose, a whole in which all facets of reality, from the size of galaxies to the thermal capacity of water, have their meaning and explanation in this central fact.Four centuries after the scientific revolution apparently destroyed irretrievably man's special place in the universe, banished Aristotle, and rendered teleological speculation obsolete, the relentless stream of discovery has turned dramatically in favor of teleology and design, and the doctrine of the microcosm is reborn. As I hope the evidence presented in this book has shown, science, which has been for centuries the great ally of atheism and skepticism, has become at last, in the final days of the second millennium, what Newton and many of its early advocates had so fervently wished - the "defender of the anthropocentric faith.
Michael Denton
The complexity of the simplest known type of cell is so great that it is impossible to accept that such an object could have been thrown together suddenly by some kind of freakish, vastly improbable, event. Such an occurrence would be indistinguishable from a miracle.
Michael Denton
How often people speak of art and science as though they were two entirely different things, with no interconnection. An artist is emotional, they think, and uses only his intuition; he sees all at once and has no need of reason. A scientist is cold, they think, and uses only his reason; he argues carefully step by step, and needs no imagination. That is all wrong. The true artist is quite rational as well as imaginative and knows what he is doing; if he does not, his art suffers. The true scientist is quite imaginative as well as rational, and sometimes leaps to solutions where reason can follow only slowly; if he does not, his science suffers.
Isaac Asimov
If a conclusion is not poetically balanced, it cannot be scientifically true.
Isaac Asimov
The most essential prediction of Darwinism is that, given an astronomical number of chances, unintelligent processes can make seemingly-designed systems, ones of the complexity of those found in the cell. ID specifically denies this, predicting that in the absence of intelligent input no such systems would develop. So Darwinism and ID make clear, opposite predictions of what we should find when we examine genetic results from a stupendous number of organisms that are under relentless pressure from natural selection. The recent genetic results are a stringent test. The results: 1) Darwinism’s prediction is falsified; 2) Design’s prediction is confirmed.
Michael J. Behe
Is the conclusion that the universe was designed - and that the design extends deeply into life - science, philosophy, religion, or what? In a sense it hardly matters. By far the most important question is not what category we place it in, but whether a conclusion is true. A true philosophical or religious conclusion is no less true than a true scientific one. Although universities might divide their faculty and courses into academic categories, reality is not obliged to respect such boundaries.
Michael J. Behe
The conclusion of intelligent design flows naturally from the data itself—not from sacred books or sectarian beliefs. Inferring that biochemical systems were designed by an intelligent agent is a humdrum process that requires no new principles of logic or science. It comes simply from the hard work that biochemistry has done over the past forty years, combined with consideration of the way in which we reach conclusions of design every day.
Michael J. Behe
Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.
Michael J. Behe
In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.
Michael J. Behe
Science is the search for the truth--it is not a game in which one tries to beat his opponent, to do harm to others. We need to have the spirit of science in international affairs, to make the conduct of international affairs the effort to find the right solution, the just solution of international problems, and not an effort by each nation to get the better of other nations, to do harm to them when it is possible. I believe in morality, in justice, in humanitarianism.
Linus Pauling
Discovery consists of looking at the same thing as everyone else and thinking something different.
Albert Szent-Györgyi
I believe in evidence. I believe in observation, measurement, and reasoning, confirmed by independent observers. I'll believe anything, no matter how wild and ridiculous, if there is evidence for it. The wilder and more ridiculous something is, however, the firmer and more solid the evidence will have to be.
Isaac Asimov
A number of years ago, when I was a freshly-appointed instructor, I met, for the first time, a certain eminent historian of science. At the time I could only regard him with tolerant condescension.I was sorry of the man who, it seemed to me, was forced to hover about the edges of science. He was compelled to shiver endlessly in the outskirts, getting only feeble warmth from the distant sun of science- in-progress; while I, just beginning my research, was bathed in the heady liquid heat up at the very center of the glow.In a lifetime of being wrong at many a point, I was never more wrong. It was I, not he, who was wandering in the periphery. It was he, not I, who lived in the blaze.I had fallen victim to the fallacy of the 'growing edge;' the belief that only the very frontier of scientific advance counted; that everything that had been left behind by that advance was faded and dead.But is that true? Because a tree in spring buds and comes greenly into leaf, are those leaves therefore the tree? If the newborn twigs and their leaves were all that existed, they would form a vague halo of green suspended in mid-air, but surely that is not the tree. The leaves, by themselves, are no more than trivial fluttering decoration. It is the trunk and limbs that give the tree its grandeur and the leaves themselves their meaning., 'it is because I have stood on the shoulders of giants.
Isaac Asimov
Have you ever come across something you couldn't explain?""Explain in what way? I could explain a ghost by saying, 'yes, that's a ghost.' I take it that's not what you mean.
Isaac Asimov
It just doesn't seem right to spend your entire life drinking, when you could be exploring the world.""Or," Zhy said as he hefted a mug to his lips, "it doesn't seem right to be risking your life running down warlocks when you could be sitting on a nice, warm bar stool.
Martin D. Gibbs
We are gaining the knowledge science is giving us that. Now we need wisdom as well.
Isaac Asimov
It is the sense of mystery that, in my opinion, drives the true scientist; the same force, blindly seeing, deafly hearing, unconsciously remembering, that drives the larva into the butterfly. If he has not experienced, at least a few times in his life, this cold shudder down his spine, this confrontation with an immense, invisible face whose breath moves him to tears, he is not a scientist. The blacker the night, the brighter the light.
Erwin Chargaff
A planet might deteriorate even if human beings existed upon it, if the society were itself abnormal and did not understand the importance of preserving the environment.""Surely," said Pelorat, "such a society would quickly be destroyed. I don't think it would be possible for human beings to fail to understand the importance of retaining the very factors that are keeping them alive."Bliss said, "I don't have your pleasant faith in human reason, Pel. It seems to me to be quite conceivable that when a planetary society consists of Isolates, local and even individual concerns might easily by allowed to overcome planetary concerns.
Isaac Asimov
It is possible to be too stable. No Outer World has colonized a new planet in two and a half centuries.. are lives too long to risk and too comfortable to upset.“I don’t know about that, Dr. Fastolfe. You’ve come to Earth. You risk disease.”“Yes, I do. There are some of us, Mr. Baley, who feel that the future of the human race is even worth the possible loss of an extended lifetime. Too few of us, I am sorry to say.”“In trying to introduce robots here on Earth, we’re doing our best to upset the balance of your City economy.”“You mean you’re creating a growing group of displaced and declassified men on purpose?”“Not out of cruelty or callousness, believe me. A group of displaced men, as you call them, are what we need to serve as a nucleus for colonization. Your ancient America was discovered by ships fitted out with men from the prisons. Don’t you see that the City’s womb has failed the displaced man. He has nothing to lose and worlds to gain by leaving Earth.
Isaac Asimov
in 2011, Rachel and I founded a company called Caribou Biosciences to commercialize the Cas proteins.
Jennifer A. Doudna
Editas Medicine has an exclusive multimillion-dollar license with Juno Therapeutics to develop T cell therapies
Jennifer A. Doudna
PGD has also been used for other controversial purposes, such as the birth if so-called savior siblings, destined from the moment of implantation not only to live their own lives, but also to serve as organ or cell donors for a sibling.
Jennifer A. Doudna
we founded Editas Medicine with $43 million in financing from three venture capital firms.
Jennifer A. Doudna
The theory of phlogiston was an inversion of the true nature of combustion. Removing phlogiston was in reality adding oxygen, while adding phlogiston was actually removing oxygen. The theory was a total misrepresentation of reality. Phlogiston did not even exist, and yet its existence was firmly believed and the theory adhered to rigidly for nearly one hundred years throughout the eighteenth century. ... As experimentation continued the properties of phlogiston became more bizarre and contradictory. But instead of questioning the existence of this mysterious substance it was made to serve more comprehensive purposes. ... For the skeptic or indeed to anyone prepared to step out of the circle of Darwinian belief, it is not hard to find inversions of common sense in modern evolutionary thought which are strikingly reminiscent of the mental gymnastics of the phlogiston chemists or the medieval astronomers.To the skeptic, the proposition that the genetic programmes of higher organisms, consisting of something close to a thousand million bits of information, equivalent to the sequence of letters in a small library of one thousand volumes, containing in encoded form countless thousands of intricate algorithms controlling, specifying and ordering the growth and development of billions and billions of cells into the form of a complex organism, were composed by a purely random process is simply an affront to reason. But to the Darwinist the idea is accepted without a ripple of doubt - the paradigm takes precedence!
Michael Denton
I, on the other hand, am a finished product. I absorb electrical energy directly and utilize it with an almost one hundred percent efficiency. I am composed of strong metal, am continuously conscious, and can stand extremes of environment easily. These are facts which, with the self-evident proposition that no being can create another being superior to itself, smashes your silly hypothesis to nothing.
Isaac Asimov
And just how did you arrive at that remarkable conclusion, Mr. Mayor?""In a rather simple way. It merely required the use of that much-neglected commodity -- common sense. You see, there is a branch of human knowledge known as symbolic logic, which can be used to prune away all sorts of clogging deadwood that clutters up human language.""What about it?" said Fulham."I applied it. Among other things, I applied it to this document here. I didn't really need to for myself because I knew what it was all about, but I think I can explain it more easily to five physical scientists by symbols rather than by words."Hardin removed a few sheets of paper from the pad under his arm and spread them out. "I didn't do this myself, by the way," he said. "Muller Holk of the Division of Logic has his name signed to the analyses, as you can see."Pirenne leaned over the table to get a better view and Hardin continued: "The message from Anacreon was a simple problem, naturally, for the men who wrote it were men of action rather than men of words. It boils down easily and straightforwardly to the unqualified statement, when in symbols is what you see, and which in words, roughly translated is, 'You give us what we want in a week, or we take it by force.'"There was silence as the five members of the Board ran down the line of symbols, and then Pirenne sat down and coughed uneasily.Hardin said, "No loophole, is there, Dr. Pirenne?""Doesn't seem to be.
Isaac Asimov
life is either a reproducible, almost commonplace manifestation of matter, given certain conditions, or a miracle. Too many steps are involved to allow for something in between.
Christian de Duve
Real arms races are run by highly intelligent, bespectacled engineers in glass offices thoughtfully designing shiny weapons on modern computers. But there's no thinking in the mud and cold of nature's trenches. At best, weapons thrown together amidst the explosions and confusion of smoky battlefields are tiny variations on old ones, held together by chewing gum. If they don't work, then something else is thrown at the enemy, including the kitchen sink - there's nothing "progressive" about that. At its usual worst, trench warfare is fought by attrition. If the enemy can be stopped or slowed by burning your own bridges and bombing your own radio towers and oil refineries, then away they go. Darwinian trench warfare does not lead to progress - it leads back to the Stone Age.
Michael J. Behe
Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.
Michael Denton
To grasp the reality of life as it has been revealed by molecular biology, we must magnify a cell a thousand million times until it is twenty kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would then see would be an object of unparalleled complexity and adaptive design. On the surface of the cell we would see millions of openings, like the port holes of a vast space ship, opening and closing to allow a continual stream of materials to flow in and out. If we were to enter one of these openings we would find ourselves in a world of supreme technology and bewildering complexity.
Michael Denton
In the discoveries of science the harmony of the spheres is also now the harmony of life. And as the eerie illumination of science penetrates evermore deeply into the order of nature, the cosmos appears increasingly to be a vast system finely tuned to generate life and organisms of biology very similar, perhaps identical, to ourselves. All the evidence available in the biological sciences supports the core proposition of traditional natural theology - that the cosmos is a specially designed whole with life and mankind as a fundamental goal and purpose, a whole in which all facets of reality, from the size of galaxies to the thermal capacity of water, have their meaning and explanation in this central fact.Four centuries after the scientific revolution apparently destroyed irretrievably man's special place in the universe, banished Aristotle, and rendered teleological speculation obsolete, the relentless stream of discovery has turned dramatically in favor of teleology and design, and the doctrine of the microcosm is reborn. As I hope the evidence presented in this book has shown, science, which has been for centuries the great ally of atheism and skepticism, has become at last, in the final days of the second millennium, what Newton and many of its early advocates had so fervently wished - the "defender of the anthropocentric faith.
Michael Denton
The complexity of the simplest known type of cell is so great that it is impossible to accept that such an object could have been thrown together suddenly by some kind of freakish, vastly improbable, event. Such an occurrence would be indistinguishable from a miracle.
Michael Denton
How often people speak of art and science as though they were two entirely different things, with no interconnection. An artist is emotional, they think, and uses only his intuition; he sees all at once and has no need of reason. A scientist is cold, they think, and uses only his reason; he argues carefully step by step, and needs no imagination. That is all wrong. The true artist is quite rational as well as imaginative and knows what he is doing; if he does not, his art suffers. The true scientist is quite imaginative as well as rational, and sometimes leaps to solutions where reason can follow only slowly; if he does not, his science suffers.
Isaac Asimov
If a conclusion is not poetically balanced, it cannot be scientifically true.
Isaac Asimov
The most essential prediction of Darwinism is that, given an astronomical number of chances, unintelligent processes can make seemingly-designed systems, ones of the complexity of those found in the cell. ID specifically denies this, predicting that in the absence of intelligent input no such systems would develop. So Darwinism and ID make clear, opposite predictions of what we should find when we examine genetic results from a stupendous number of organisms that are under relentless pressure from natural selection. The recent genetic results are a stringent test. The results: 1) Darwinism’s prediction is falsified; 2) Design’s prediction is confirmed.
Michael J. Behe
Is the conclusion that the universe was designed - and that the design extends deeply into life - science, philosophy, religion, or what? In a sense it hardly matters. By far the most important question is not what category we place it in, but whether a conclusion is true. A true philosophical or religious conclusion is no less true than a true scientific one. Although universities might divide their faculty and courses into academic categories, reality is not obliged to respect such boundaries.
Michael J. Behe
The conclusion of intelligent design flows naturally from the data itself—not from sacred books or sectarian beliefs. Inferring that biochemical systems were designed by an intelligent agent is a humdrum process that requires no new principles of logic or science. It comes simply from the hard work that biochemistry has done over the past forty years, combined with consideration of the way in which we reach conclusions of design every day.
Michael J. Behe
Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.
Michael J. Behe
In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.
Michael J. Behe