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- Page 498
Depression is partly a nocebo effect, in the sense that it can be produced by negative exceptions about oneself and the world. The way in which these negative expectations develop and produce their negative effects provides some clues as to how they can be reversed. Expectancy effects grow, feeding upon themselves. One reason this happens is that our subjective states - our feelings, our moods and sensations - are in constant flux, changing from day to day and from moment to moment. The effects of these fluctuations depend on how we interpret them, and our interpretations depend on our beliefs and expectations. When we expect to feel worse, we tend to notice random small negative changes and interpret them as evidence that we are in fact getting worse. This interpretation makes us actually feel worse, and it strengthens the belief that we are getting worse, leading to a vicious cycle in which our expectations and negative emotions feed on each other, cascading into a full-blown depressive episode. .. Positive expectancies have the opposite effect. They can set in motion a begin cycle, in which random fluctuations in mood and well being are interpreted as evidence of treatment effectiveness, thereby instilling a further sense of hope and countering the feeling of hopelessness that are so central to clinical depression.
Irving Kirsch
The results of decades of neurotransmitter-depletion studies point to one inescapable conclusion: low levels or serotonin, norepinephrine or dopamine do not cause depression. here is how the authors of the most complete meta-analysis of serotonin-depletion studies summarized the data: "Although previously the monoamine systems were considered to be responsible for the development of major depressive disorder (MDD), the available evidence to date does not support a direct causal relationship with MDD. There is no simple direct correlation of serotonin or norepinephrine levels in the brain and mood.' In other words, after a half-century of research, the chemical-imbalance hypothesis as promulgated by the drug companies that manufacture SSRIs and other antidepressants is not only with clear and consistent support, but has been disproved by experimental evidence.
Irving Kirsch
…she felt depressed beyond any thing she had ever known before.
Jane Austen
Eventually sinking into despair, [Heinrich von Kleist] shot himself in 1811 as part of a suicide pact made with a woman suffering from incurable cancer.
Nicholas Tucker
He did not care what the end would be, and in his lucid moments overvalued his indifference. The danger, when not seen, has the imperfect vagueness of human thought. The fear grows shadowy; and Imagination, the enemy of men, the father of all terrors, unstimulated, sinks to rest in the dullness of exhausted emotion.
Joseph Conrad
He's following me... He needs to have a secret but he can´t help telling the heat is going out of me. The heart is going out of me, and though she cannot remember she cannot forget. Clutching a fistful of sand. What ties me to you is guilt. I crossed two rivers and wept by one I am the beast at the end of the rope Happy and free.
Sarah Kane
At the best of times, spring hurts depressives.
Angela Carter
Depression is a serious problem, but drugs are not the answer. In the long run, psychotherapy is both cheaper and more effective, even for very serious levels of depression. Physical exercise and self-help books based on CBT can also be useful, either alone or in combination with therapy. Reducing social and economic inequality would also reduce the incidence of depression.
Irving Kirsch
Squiffy, have you ever felt a sort of strange emptiness in the heart? A sort of aching void of the soul?''Oh, rather!''What do you do about it?''I generally take a couple of cocktails.
P.G. Wodehouse
Master Nathaniel looked at him. The fixed stare, the slightly-open mouth, the rigid motionless body, fettered by a misery too profound for restlessness — how well he knew the state of mind these things expressed! But there must surely be relief in thus allowing the mood to mould the body's attitude to its own s
Hope Mirrlees
The message of this lecture is that black holes ain’t as black as they are painted. They are not the eternal prisons they were once though…things can get out of a black hole both on the outside and possibly to another universe. So if you feel you are in a black hole, don’t give up – there’s a way out.
Stephen Hawking
Depression comes in bouts. Like boxing. Dad is in the blue corner.
Joe Dunthorne
For people who are depressed, and especially for those who do not receive enough benefit from medication of for whom the side effects of antidepressants are troubling, the fact that placebos can duplicate much of the effects of antidepressants should be taken as good news. It means that there are other ways of alleviating depression. As we have seen, treatments like psychotherapy and physical exercise are at least as effective as antidepressant drugs and more effective than placebos. In particular, CBT has been shown to lower the risk of relapsing into depression for years after treatment has ended, making it particularly cost effective.
Irving Kirsch
Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances.The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence.
Irving Kirsch
Finally, there was the impediment of his nature. In the secret parts of his peculiar brain, those unhappy and inextricable tangles which he felt at the roots, the boy was disabled by something which we cannot explain. He could not have explained either, and for us it is all too long ago. He loved Arthur and he loved Guenever and he hated himself. The best knight of the world: everybody envied the self-esteem which must surely be his. But Lancelot never believed he was good or nice. Under the grotesque, magnificent shell with a face like Quasimodo’s, there was shame and self-loathing which had been planted there when he was tiny, by something which it is now too late to trace. It is so fatally easy to make young children believe that they are horrible.
T.H. White
Sometimes I think depression should be called the coping illness. So many of us struggle on, not daring or knowing how to ask for help. More of us, terribly, go undiagnosed.
Sally Brampton
No worst, there is none. Pitched past pitch of grief,More pangs will, schooled at forepangs, wilder wring.Comforter, where, where is your comforting?Mary, mother of us, where is your relief?My cries heave, herds-long; huddle in a main, a chief-woe, world-sorrow; on an age-old anvil wince and sing —Then lull, then leave off. Fury had shrieked 'No ling-ering! Let me be fell: force I must be brief'.O the mind, mind has mountains; cliffs of fallFrightful, sheer, no-man-fathomed. Hold them cheapMay who ne'er hung there. Nor does long our smallDurance deal with that steep or deep. Here! creep,Wretch, under a comfort serves in a whirlwind: allLife death does end and each day dies with sleep.
Gerard Manley Hopkins
...we can love someone without understanding that person.
Dorothy Rowe
Even extreme grief may ultimately ventitself in violence--but more generally takes the form of apathy
Joseph Conrad
Bad enough to be ill, but to feel compelled to deny the very thing that, in its worst and most active state, defines you is agony indeed.
Sally Brampton
Depression is not caused by a chemical imbalance in the brain, and it is not cured by medication. Depression may not even be an illness at all. Often, it can be a normal reaction to abnormal situations. Poverty, unemployment, and the loss of loved ones can make people depressed, and these social and situational causes of depression cannot be changed by drugs.
Irving Kirsch
The return of the voices would end in a migraine that made my whole body throb. I could do nothing except lie in a blacked-out room waiting for the voices to get infected by the pains in my head and clear off. Knowing I was different with my OCD, anorexia and the voices that no one else seemed to hear made me feel isolated, disconnected. I took everything too seriously. I analysed things to death. I turned every word, and the intonation of every word over in my mind trying to decide exactly what it meant, whether there was a subtext or an implied criticism. I tried to recall the expressions on people’s faces, how those expressions changed, what they meant, whether what they said and the look on their faces matched and were therefore genuine or whether it was a sham, the kind word touched by irony or sarcasm, the smile that means pity. When people looked at me closely could they see the little girl in my head, being abused in those pornographic clips projected behind my eyes? That is what I would often be thinking and such thoughts ate away at the façade of self-confidence I was constantly raising and repairing. (describing dissociative identity disorder/mpd symptoms)
Alice Jamieson
But it only takes a doubt. A drop of ink falls into a clear glass of water and clouds the whole thing. So the moment after I realised I wasn't perfectly well was the moment I realised I was still very ill indeed.
Matt Haig
Like antidepressants, a substantial part of the benefit of psychotherapy depends on a placebo effect, or as Moerman calls it, the meaning response. At least part of the improvement that is produced by these treatments is due to the relationship between the therapist and the client and to the client's expectancy of getting better. That is a problem for antidepressant treatment. It is a problem because drugs are supposed to work because of their chemistry, not because of the psychological factors. But it is not a problem for psychotherapy. Psychotherapists are trained to provide a warm and caring environment in which therapeutic change can take place. Their intention is to replace the hopelessness of depression with a sense of hope and faith in the future. These tasks are part of the essence of psychotherapy. The fact that psychotherapy can mobilize the meaning response - and that it can do so without deception - is one of its strengths, no one of its weaknesses. Because hopelessness is a fundamental characteristic of depression, instilling hope is a specific treatment for it it. Invoking the meaning response is essential for the effective treatment of depression, and the best treatments are those that can do this most effectively and that can do without deception.
Irving Kirsch
I enjoy almost everything. Yet I have some restless searcher in me. Why is there not a discovery in life? Something one can lay hands on and say “This is it”? My depression is a harassed feeling. I’m looking: but that’s not it — that’s not it. What is it? And shall I die before I find it?
Virginia Woolf
As to whether the depression will come back, it is every depressive's fear.
Sally Brampton
No reason to feel depressed about being depressed. A depression can be a golden opportunity to collect the pieces and build ourselves anew. Global Souls are always on the move, nomads at heart, connected to various cities, commuters between cultures, both from here and everywhere.
Elif Shafak
Imagine saying to somebody that you have a life-threatening illness, such as cancer, and being told to pull yourself together or get over it.Imagine being terribly ill and too afraid to tell anyone lest it destroys your career.Imagine being admitted to hospital because you are too ill to function and being too ashamed to tell anyone, because it is a psychiatric hospital.Imagine telling someone that you have recently been discharged and watching them turn away, in embarrassment or disgust or fear.Comparisons are odious. Stigmatising an illness is more odious still.
Sally Brampton
A friend called the other day.'How are you?' she said.The sun was shining, the sky a merciless blue. It was only eleven in the morning but I had been awake since three twenty. I was in bed because, as usual, I could think of nowhere else to go. I said that I was feeling low. Low is the depressive's euphemism for despair.She said: 'How can you be depressed on a day like this?'I wanted to say: 'If I had flu, would you ask me how I could be sick on a day like this?
Sally Brampton
I've started to hate this city, this country, all these STUPID FUCKING PEOPLE.
Nick Bantock
Misery is a no U-turns, no stopping road. Travel down it pushed by those behind, tripped by those in front. Travel down it at furious speed though the days are mummified in lead. It happens so fast once you get started, there’s no anchor from the real world to slow you down, nothing to hold on to. Misery pulls away the brackets of life leaving you to free fall. Whatever your private hell, you’ll find millions like it in Misery. This is the town where everyone’s nightmares come true.
Jeanette Winterson
It's as if a child with a brush and too much enthusiasm has been set free with a tin of black paint inside me.
Jenny Downham
Embrace the void and have the courage to exist.
Dan Howell
MINDS ARE UNIQUE. They go wrong in unique ways. My mind went wrong in a slightly different way to how other minds go wrong. Our experience overlaps with other people's, but it is never exactly the same experience.
Matt Haig
You see, people in the depressive position are often stigmatised as ‘failures' or ‘losers'. Of course, nothing could be further from the truth. If these people are in the depressive position, it is most probably because they have tried too hard or taken on too much, so hard and so much that they have made themselves ‘ill with depression'. In other words, if these people are in the depressive position, it is because their world was simply not good enough for them. They wanted more, they wanted better, and they wanted different, not just for themselves, but for all those around them. So if they are failures or losers, this is only because they set the bar far too high. They could have swept everything under the carpet and pretended, as many people do, that all is for the best in the best of possible worlds. But unlike many people, they had the honesty and the strength to admit that something was amiss, that something was not quite right. So rather than being failures or losers, they are just the opposite: they are ambitious, they are truthful, and they are courageous. And that is precisely why they got ‘ill'. To make them believe that they are suffering from some chemical imbalance in the brain and that their recovery depends solely or even mostly on popping pills is to do them a great disfavour: it is to deny them the precious opportunity not only to identify and address important life problems, but also to develop a deeper and more refined appreciation of themselves and of the world around them—and therefore to deny them the opportunity to fulfil their highest potential as human beings.
Neel Burton
Not Waving but Drowning Nobody heard him, the dead man, But still he lay moaning: I was much further out than you thought And not waving but drowning. Poor chap, he always loved larking And now he's dead It must have been too cold for him his heart gave way, They said. Oh, no no no, it was too cold always (Still the dead one lay moaning) I was much too far out all my life And not waving but drowning.
Stevie Smith
It’s so difficult to describe depression to someone who’s never been there, because it’s not sadness. I know sadness. Sadness is to cry and to feel. But it’s that cold absence of feeling— that really hollowed-out feeling.
J.K. Rowling
They say that depression makes you see everything in a negative light. I disagree. It makes you see things for what they are. It makes you take off the fucking rose-tinted glasses and look around and see the world as it really is- cruel, harsh and unfair. It makes you see people in their true colours- stupid, shallow and self-absorbed. All that ridiculous optimism, all that carpe diem and life-is-what-you-make-of-it. Words, jsut empty words in an attempt to give meaning to an existence taht is both doomed and futile.
Tabitha Suzuma
We are not easy to help. Nor are we easy to be around. Nobody with a serious illness is easy to be around. Although not obviously physically disabled, we struggle to get things done. Our energy levels are dangerously low. Sometimes, we find it hard to talk. We get angry and frustrated. We fall into despair. We cry, for no apparent reason. Sometimes we find it difficult to eat, or to sleep. Often, we have to go to bed in the afternoon or all day.So do most people with a serious illness. We are no different.
Sally Brampton
When the black thing was at its worst, when the illicit cocktails and the ten-mile runs stopped working, I would feel numb as if dead to the world. I moved unconsciously, with heavy limbs, like a zombie from a horror film. I felt a pain so fierce and persistent deep inside me, I was tempted to take the chopping knife in the kitchen and cut the black thing out I would lie on my bed staring at the ceiling thinking about that knife and using all my limited powers of self-control to stop myself from going downstairs to get it.
Alice Jamieson
But about the drip drip of long-haul, no-end-in-sight solitude, they know nothing. They don't know what it is to construct an entire weekend around a visit to the laundrette. Or to sit in a darkened flat on Halloween night, because you can't bear to expose your bleak evening to a crowd of jeering trick-or-treaters. Or to have the librarian smile pityingly and say, ‘Goodness, you're a quick reader!’ when you bring back seven books, read from cover to cover, a week after taking them out. They don't know what it is to be so chronically untouched that the accidental brush of a bus conductor's hand on your shoulder sends a jolt of longing straight to your groin.
Zoë Heller
I suppose this was the first time I had ever felt an urge not to be. Never an urge to die, far less an urge to put an end to myself - simply an urge not to be. This disgusting, hostile and unlovely world was not made for me, nor I for it.
Stephen Fry
And another way of explaining it is to say that shit happens, and there's no space too small, too dark and airless and fucking hopeless, for people to crawl into.
Nick Hornby
I have a sense of melancholy isolation, life rapidly vanishing, all the usual things. It's very strange how often strong feelings don't seem to carry any message of action.
Philip Larkin
Depression - that limp word for the storm of black panic and half-demented malfunction - had over the years worked itself out in Charlotte's life in a curious pattern. Its onset was often imperceptible: like an assiduous housekeeper locking up a rambling mansion, it noiselessly went about and turned off, one by one, the mind's thousand small accesses to pleasure.
Sebastian Faulks
Sometimes," says a fellow depressive, "I wish I was in a full body cast, with every bone in my body broken. That's how I feel anyway. Then, maybe, people would stop minimising my illness because they can actually see what's wrong with me. They seem to need physical evidence.
Sally Brampton
You can tell a lot from a person's nails. When a life starts to unravel, they're among the first to go.
Ian McEwan
I am in that temper that if I were under water I would scarcely kick to come to the top.
John Keats
You're fucked. You thought you were going to be someone, but now it's obvious you're nobody. You haven't got as much talent as you thought you had, and there was no Plan B, and you got no skills and no education, and now you're looking at forty or fifty years of nothing. Less than nothing, probably. That's pretty heavy. That's worse than having the brain thing, because what you got now will take a lot longer to kill you. You've got the choice of a slow, painful death, or a quick, merciful one.
Nick Hornby
It's brilliant, being depressed; you can behave as badly as you like.
Nick Hornby
Depression is the most unpleasant thing I have ever experienced. . . . It is that absence of being able to envisage that you will ever be cheerful again. The absence of hope. That very deadened feeling, which is so very different from feeling sad. Sad hurts but it's a healthy feeling. It is a necessary thing to feel. Depression is very different.
J.K. Rowling
You say you're 'depressed' - all i see is resilience. You are allowed to feel messed up and inside out. It doesn't mean you're defective - it just means you're human.
David Mitchell
Killing oneself is, anyway, a misnomer. We don't kill ourselves. We are simply defeated by the long, hard struggle to stay alive. When somebody dies after a long illness, people are apt to say, with a note of approval, "He fought so hard." And they are inclined to think, about a suicide, that no fight was involved, that somebody simply gave up. This is quite wrong.
Sally Brampton
Noble deeds and hot baths are the best cures for depression.
Dodie Smith
Each word's evocative value or virtue, its individual power of touching springs in the mind and of initiating visions, becomes a treasure to revel in. Besides this hold on affection a word may well have about it the glamorous prestige of high adventures in great company. Think of that the plain word "dust" calls to mind. "Then shall the dust return to the earth as it was." "Dust hath closed Helen's eye." "All follow this and come to dust." "The way to dusty death." So, to the lover of words, each word may be not a precious stone only, but one that has shone on Solomon's temple or in Cleopatra's hair.
C.E. Montague
I can feel the power of the words doing the work. Must trust language more.
Antony Sher
Language is the expression of ideas by means of speech-sounds combined into words. Words are combined into sentences, this combination answering to that of ideas into thoughts.
Henry Sweet
Some people make tunes, but it is lines that run like moving messages through my head. Whatever else I am saying and doing often has no bearing on this inner, verbal life.
Susan Hill
There is great worth in holding universal truths and timelessly beautiful words in your heart, which will stay there forever, infusing your thoughts and speech…
Dan Stevens
Words can be a fortress or a drawbridge to disaster
Benny Bellamacina
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